Andrew, the possibility of using ITB's for an FI application is going to move this interesting discussion into a yet another area.
For me, the primary technical justification for ITB's is the improved throttle response you can gain with them on an NA motor. Simplistically, giving each hole its own butterfly means that hole isn't competing with the other holes anymore for the same air.
In a turbo application, the response of the engine is probably going to be more affected by the inertia of the turbo upstream. In some conditions, (such as prespool) the turbo is actually going to add a restriction in the intake, so it really wouldn't matter whether the motor is "pulling" from one big butterfly or 8 little ones. When the throttle is banged open, the poor motor is trying to suck air through a "straw" which is the entire intake system, c/o piping, intercooler, more piping, turbo, more piping, MAF and an intake filter. It would be interesting to put a pressure sensor in the intake system and see just how much the air pressure drops in these instances. (This is like trying to suck a thick milkshake through a small straw.)
But then, this situation should change completely once the turbo is on boost (it's now "pushing" more air through the straw than the motor wants) Now, when the ITB's are cracked open a bit more, the response should be "much" faster than having a single TB just upstream of a fairly large plenum, with a pretty big deltaP separating the pressure in that plenum and the pressure upstream of the TB.
To me, this sounds like a great argument for having ITB's in a supercharged application, and having positive pressure available in the system all the time, just in front of the butterflies. It probably wouldn't be practical to try this with a roots or twinscrew sitting on a Richwood manifold due to the lack of space, but it would be waaaaay cool to try with one of the centrifugal SC setups. I don't know if KC is reading this, but he's been fighting the "lag" monster recently, and has been fine tuning his setup to try and reduce the volume of the intake system between the centrifugal SC and the motor. But.....if he had that entire volume pressurised all the time with more air than the motor needs, then by definition, there should be zero lag.
Does this make any sense, or is it time to put the crack pipe down?