With the right turbo and TUNE with fuel supply to match power levels plus 20% safety margin..
The engine needs to be strong enough to make any reasonable power you want..
Turbo's or forced induction makes it so easy..
But a bad tune will kill any engine...
Lowering compression a little.. 9.5 on pentroof head gives some window for safe tune also...
Toyota did a good job on most there engines in this area..
Being 4 bolt on iron block won't weaken anything..
Keep in mind the iron block is used for durability in SUV's...